Ovarian ectopic pregnancy: a rare condition

Pregnancy of extra-uterine origin can be a serious condition that demands early diagnosis and prompt treatment to save life of the women. Apart from tubal ectopic, ovarian ectopic pregnancy is the second common but rare type of extra-uterine pregnancy. A patient who has been using long term injectable contraception presented with 8 weeks amenorrhea followed by irregular bleeding per vaginum. Spiegelberg criteria were fulfilled. Laparotomy and histopathology confirmed ovarian ectopic pregnancy.

Women's preferences for place of delivery: a study at tertiary care hospital

Objective: To determine the preference for choice of birth place among pregnant women attending antenatal clinics at tertiary care Hospital. To find out the barriers which make their choices

Study Design: Prospective descriptive study

Place and Duration: This study was done in the Department of Obstetrics and Gynecology Isra University Hospital from January 2010 to July 2010

Methodology: In this study pregnant women [n = 912] attending antenatal clinics, were interviewed to collect data regarding socio demographic profile. Women views about their preferences for home delivery and hospital confinement were assessed. The data was recorded on structured questionnaires analyzed by SPSS version 16 and presented as frequencies and percentages

Results: It was observed that 553 [60.63%] of study participant preferred hospital birth. The main reasons for choosing hospital delivery were safety and good care 260 [47% of the women], better hygiene 138 [25%] and because of medical advice and services 70 [12 %]. About 359 [39. 36 %] were liked home birth reason were social support and privacy and good care at home 141 [40%] low cost 135 [38%] new born care being taken at home 44 [12.25] and local hygiene 17 [4 %] respectively

Conclusion: Majority of our study participant were preferred hospital birth because of provision of good care and safety. Social pressure were common in those who delivered at home so women preference should be acknowledged

Hepatoprotective role of zinc sulphate in acetaminophen-induced liver toxicity

Objective: To determine the role of zinc sulphate as a hepatoprotective agent in acetaminophen-induced histopathological changes in animal model

Design:Experimental observational study

Setting: Department of Pharmacology and Pathology, ISRA University, Hyderabad and Department of Pathology, Peoples Medical College, Nawabshah

Duration: 1 st December 2009 to 31 st March 2010

Methodology: Ninety healthy albino rats [weight 18-32 g] were divided into three main groups [n=30]. Group A, which served as control, was maintained on 0.9% normal saline; Group B was given acetaminophen 250 mg/kg as a single dose; Group C was maintained on 1-5 mg/kg zinc sulphate for 1-7 days, before a single dose of acetaminophen 250 mg/kg. Biochemical studies were done 6 hours after acetaminophen administration. At the end of the treatment, all animals were weighed and sacrificed, the liver excised for gross and histopathological examination. Data were statistically evaluated using the Chi- square test

Results: The protective effect of zinc was demonstrated with the reduction in the levels of serum concentration of liver enzymes [aspartate aminotransferase, alanine aminotransferase, lactate dehydrogenase, and serum sorbitol dehydrogenase], with histopathological changes of centrilobular congestion, and hepatocellular degeneration and necrosis. Histopathological assessment showed typical pathological changes of centrizonal necrosis, steatosis, leukocyte infiltration, portal triaditis, and edema in those animals that received acetaminophen only. Pretreatment of the animals with zinc sulphate led to dose- dependent avoidance of these changes

Conclusion: Zinc produces a hepatoprotective effect by preventing the ultrastructural injury of hepatic tissue and the disturbance of free amino acid metabolism caused by a toxic dose of acetaminophen

Frequency of endometrial carcinoma in histopathology of hysterectomy specimen in Hyderabad

This study was conducted to find the frequency of endometrial carcinoma in histopathology specimens in Hyderabad. Descriptive study. All hysterectomy specimens received in the histopathology department of Isra University Hyderabad and Liaquat University of Medical and Health Sciences Hyderabad during the period of January 2005 to December 2006 were collected. A randomized study of 100 cases undergoing hysterectomy was carried out. Maximum number of women who underwent hysterectomy was in the age group of 25-75 years. Two proformas were designed to get the clinical information and gross and histopathological findings. Specimens were preserved in 10% formalin and thorough naked eye examination was done. Representative blocks were taken and processed for paraffin embedding out of 100 cases, endometrial carcinoma was found in 07 [7%] cases. Mean age of the patient was 43.06 +/- 7.34 years while the mean age of endometrial carcinoma was 50.71 +/- 9.32 years. Abnormal menstrual flow was the most common complaint. Most of the cases [N=06] were present in group B that is above the age of 40 years. Furthermore out of these 07 diagnosed cases, 06 cases were present in multiparous women while only one case was found in nulliparous woman. Frequency of endometrial carcinoma is 7% in women of Hyderabad. It is more common above the age of 40 years and in mlutiparous and grandmultiparous women

Clinico-pathological analysis of hysterectomies in various age groups at Hyderabad, Pakistan

To study the frequency and pattern of benign, premalignant, and malignant lesion in hystrectomized uteri and perform clinic-pathological analysis. All hysterectomy specimens received in the histopathology departments of Isra University Hyderabad and Liaquat University of Medical and Health Sciences Hyderabad during the period of January 2005 to December 2006 were studied. A randomized study of 100 cases undergoing hysterectomy was carried out and clinicopathological analysis was done. Most women who underwent hysterectomy were in the age group of 25-75 years. Two proformas were designed to record the clinical information and gross and histopathological findings. Specimens were preserved in 10% formalin and thorough gross examination was done. Representative blocks were processed for paraffin embedding. Abnormal menstrual flow was the most common complaint. Mean age of the patient was 43.06 +/- 7.34 years. Out of 100 cases, endometrial diseases were the most common finding [in67% of the cases] followed by adenomyosis [47%], leiomyoma [32%], cervical intraepithelial neoplastic changes [04%], and invasive cervical carcinoma [03%]. This study concludes that benign uterine lesions are common, consisting mostly of endometrial hyperplasia, leiomyoma, and adenomyosis, and are almost equally present in women above and below the age of 40 years in Hyderabad with the exception of endometrial carcinoma and invasive cervical carcinoma which were commonly found above 40 years of age